Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh

Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2009-07, Vol.28 (7), p.767-773
Main Authors: Nahar, S, Kibria, K. M. K, Hossain, Md. E, Sultana, J, Sarker, S. A, Engstrand, L, Bardhan, P. K, Rahman, M, Endtz, H. P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial infections
Bacterial Typing Techniques
Bangladesh - epidemiology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Child
Child, Preschool
Developing countries
DNA Fingerprinting - methods
DNA, Bacterial - genetics
Families & family life
Family Health
Female
Genetic engineering
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter Infections - transmission
Helicobacter pylori
Helicobacter pylori - classification
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Industrialized nations
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Internal Medicine
LDCs
Low income groups
Male
Medical Microbiology
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Molecular Epidemiology
Polymerase Chain Reaction
Random Amplified Polymorphic DNA Technique
Socioeconomic factors
Young Adult
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Summary:Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.
ISSN:0934-9723
1435-4373
1435-4373
DOI:10.1007/s10096-008-0699-8