Backbone Carbonyl Group Basicities Are Related to Gas-Phase Fragmentation of Peptides and Protein Folding

A strong correlation is found between the propensity of individual amino acids to induce peptide‐bond cleavage in the gas phase (PAA–XX) and their structure‐forming propensity (PS, red) and H‐bond‐accepting propensity (PH, blue). Thus, the same fundamental parameter, carbonyl group basicity, governs...

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Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (9), p.1481-1484
Main Authors: Savitski, Mikhail M., Kjeldsen, Frank, Nielsen, Michael L., Garbuzynskiy, Sergiy O., Galzitskaya, Oxana V., Surin, Alexey K., Zubarev, Roman A.
Format: Article
Language:English
Subjects:
Amino Acids - chemistry
Chemistry
Gases - chemistry
hydrogen bonds
Kemi
mass spectrometry
Medicin och hälsovetenskap
NATURAL SCIENCES
NATURVETENSKAP
peptide fragmentation
Peptide Fragments - chemistry
Protein Folding
protein structures
Proteins - chemistry
proteomics
Spectrometry, Mass, Electrospray Ionization
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Summary:A strong correlation is found between the propensity of individual amino acids to induce peptide‐bond cleavage in the gas phase (PAA–XX) and their structure‐forming propensity (PS, red) and H‐bond‐accepting propensity (PH, blue). Thus, the same fundamental parameter, carbonyl group basicity, governs the formation of secondary protein structures in solution and directs fragmentation in the gas phase.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200603881