Investigation of idiopathic inflammatory myopathy for shared genetic risk factors with other autoimmune diseases: results from the European Myositis Network

Abstract Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterised by inflammation of muscles. They may present as a primary disorder or may overlap with other diseases such as rheumatoid arthritis, systemic lupus erythematosus, or systemic sclerosis. The...

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Bibliographic Details
Published in:LANCET 2013, Vol.381, p.S56-S56
Main Authors: Jani, M, Dr, Chinoy, H, Lamb, JA, Wedderburn, L, Vencovsky, J, Danko, K, Lundberg, I, O'Callaghan, A Selva, Radstake, T, Platt, H, Ollier, WE, Cooper, RG
Format: Article
Language:English
Subjects:
adults
Autoimmune diseases
biomedical research
celiac disease
dermatomyositis
Environmental factors
genes
Genetic variance
inflammation
inflammatory bowel disease
insulin-dependent diabetes mellitus
Internal Medicine
lupus erythematosus
Medical research
Medicin och hälsovetenskap
meta-analysis
Muscles
polymyositis
Psoriasis
Quality control
Rheumatoid arthritis
Risk factors
sclerosis
single nucleotide polymorphism
Skin diseases
Systematic review
Whites
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Summary:Abstract Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterised by inflammation of muscles. They may present as a primary disorder or may overlap with other diseases such as rheumatoid arthritis, systemic lupus erythematosus, or systemic sclerosis. The cause of IIM is largely unknown, but is thought to include a combination of both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified many genetic variants associated with autoimmune disorders, several of which are common to multiple disorders. We tested the hypothesis that genetic risk factors associated with other autoimmune disorders also predispose to IIM. Methods Single-nucleotide polymorphisms (SNPs) significantly associated with systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, coeliac disease, inflammatory bowel disease, psoriasis, type 1 diabetes, multiple sclerosis, and systemic sclerosis were identified from published GWAS in white populations. 233 unique SNPs were identified (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(13)60496-1