The Clinical Relevance of Gastrointestinal Endoscopy in Pediatric Patients with Suspected Gastrointestinal Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

Background and aim: Graft-versus-host disease (GVHD) affecting visceral organs is a severe complication of hematopoietic stem cell transplantation (HSCT). GVHD in the gastrointestinal tract (GI-GVHD) is primarily a clinical-based diagnosis, but due to non-specific symptoms histopathology verificatio...

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Bibliographic Details
Published in:Blood 2014-12, Vol.124 (21), p.3926-3926
Main Authors: Mårtensson, Thomas, Mellgren, Karin, Toporski, Jacek, Matttson, Jonas, Szakos, Attila, Casswall, Thomas, Gustafsson, Britt
Format: Article
Language:English
Subjects:
Medicin och hälsovetenskap
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Summary:Background and aim: Graft-versus-host disease (GVHD) affecting visceral organs is a severe complication of hematopoietic stem cell transplantation (HSCT). GVHD in the gastrointestinal tract (GI-GVHD) is primarily a clinical-based diagnosis, but due to non-specific symptoms histopathology verification is recommended. Data in children concerning the efficacy of endoscopic examination performed due to clinically suspected GI-GVHD is scarce. The aim of this study was to investigate the modification of the pharmacological treatment regimen based on the gastrointestinal histopathology report. Material and Methods: A retrospective clinical study from 3 out of 4 transplantation(s) centers in Sweden including 62 children (40 boys, 22 girls) were enrolled. The patients underwent HSCT during 2000-2012. Endoscopy with biopsies, were performed due to clinically suspected GI-GVHD,
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V124.21.3926.3926