Metabolic restructuring and cell fate conversion

Accumulating evidence implicates mitochondrial and metabolic pathways in the establishment of pluripotency, as well as in the control of proliferation and differentiation programs. From classic studies in mouse embryos to the latest findings in adult stem cells, human embryonic and induced pluripote...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2015-05, Vol.72 (9), p.1759-1777
Main Authors: Prigione, Alessandro, Ruiz-Pérez, María Victoria, Bukowiecki, Raul, Adjaye, James
Format: Article
Language:English
Subjects:
Animals
biochemical pathways
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Proliferation
Cellular biology
Cellular Reprogramming
Energy Metabolism
Epigenetics
Humans
induced pluripotent stem cells
Life Sciences
Medicin och hälsovetenskap
medicine
Metabolic Networks and Pathways
Metabolism
mice
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Review
Stem cells
therapeutics
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Summary:Accumulating evidence implicates mitochondrial and metabolic pathways in the establishment of pluripotency, as well as in the control of proliferation and differentiation programs. From classic studies in mouse embryos to the latest findings in adult stem cells, human embryonic and induced pluripotent stem cells, an increasing number of evidence suggests that mitochondrial and metabolic-related processes might intertwine with signaling networks and epigenetic rewiring, thereby modulating cell fate decisions. This review summarizes the progresses in this exciting field of research. Dissecting these complex mitochondrial and metabolic mechanisms may lead to a more comprehensive understanding of stemness biology and to potential improvements in stem cell applications for biomedicine, cell therapy, and disease modeling.
ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-015-1834-1