Recent advances in research on Crimean-Congo hemorrhagic fever

Abstract Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as...

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Bibliographic Details
Published in:Journal of clinical virology 2015-03, Vol.64, p.137-143
Main Authors: Papa, Anna, Mirazimi, Ali, Köksal, Iftihar, Estrada-Pena, Augustin, Feldmann, Heinz
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antiviral Agents - therapeutic use
Communicable Diseases, Emerging
Crimean-Congo hemorrhagic fever
Ecology
Epidemiology
Hemorrhagic Fever Virus, Crimean-Congo - immunology
Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity
Hemorrhagic Fever, Crimean - diagnosis
Hemorrhagic Fever, Crimean - epidemiology
Hemorrhagic Fever, Crimean - prevention & control
Hemorrhagic Fever, Crimean - therapy
Humans
Infectious Disease
Medicin och hälsovetenskap
Ticks - virology
Viral Vaccines
Zoonoses
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Summary:Abstract Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.
ISSN:1386-6532
1873-5967
1873-5967
DOI:10.1016/j.jcv.2014.08.029