Cataract after allogeneic hematopoietic stem cell transplantation in childhood

Aim The aim of this study was to study long‐term visual outcome and cataract development in children and adolescents after hematopoietic stem cell transplantation (HSCT) in childhood. Methods Best corrected visual acuity (BCVA), refraction and lens status were examined in a prospective study of 139...

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Bibliographic Details
Published in:Acta Paediatrica 2016-01, Vol.105 (1), p.82-89
Main Authors: Teär Fahnehjelm, Kristina, Törnquist, Alba Lucia, Olsson, Monica, Bäckström, Ingrid, Andersson Grönlund, Marita, Winiarski, Jacek
Format: Article
Language:English
Subjects:
Adolescent
BONE-MARROW-TRANSPLANTATION
Cataract
Cataract - diagnosis
Cataract - etiology
Child
Child, Preschool
CHILDREN
Female
Follow-Up Studies
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Infant
Kaplan-Meier Estimate
Male
Medicin och hälsovetenskap
OCULAR COMPLICATIONS
Oftalmologi
Ophthalmology
Pediatrics
Pediatrik
Proportional Hazards Models
Prospective Studies
QUALITY-OF-LIFE
SURVIVORS
TOTAL-BODY IRRADIATION
VERSUS-HOST-DISEASE
Visual outcome
Young Adult
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Summary:Aim The aim of this study was to study long‐term visual outcome and cataract development in children and adolescents after hematopoietic stem cell transplantation (HSCT) in childhood. Methods Best corrected visual acuity (BCVA), refraction and lens status were examined in a prospective study of 139 children and adolescents. Results In total, 139 patients (58 female), median age 6.6 years at HSCT (range 0.4–17.5 years), were followed up for a median of 8.0 years (1–19.4 years). Median BCVA in the better eye was 1.0 decimal. Altogether 19 of 131 patients developed cataract requiring surgery, while 46 developed less prominent lens opacities and 66 had clear lenses at time of latest follow‐up. Patients conditioned with total body irradiation had a higher risk of developing lens opacities or cataract (p 
ISSN:0803-5253
1651-2227
1651-2227
DOI:10.1111/apa.13173