Metabolic Control of Longevity

Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence meta...

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Bibliographic Details
Published in:Cell 2016-08, Vol.166 (4), p.802-821
Main Authors: López-Otín, Carlos, Galluzzi, Lorenzo, Freije, José M.P., Madeo, Frank, Kroemer, Guido
Format: Article
Language:English
Subjects:
Aging - blood
Aging - metabolism
Animals
Caloric Restriction
Cellular Senescence
Diet
Diet, Western
Exercise
Humans
Life Style
Longevity
Medicin och hälsovetenskap
Metformin - administration & dosage
Mitochondria - metabolism
Stress, Physiological
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Summary:Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans. Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a “metabolic clock” that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the “westernized” lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2016.07.031