Temporal processing capacity in auditory-deprived superior paraolivary neurons is rescued by sequential plasticity during early development

Highlights • Streaming of temporal acoustic cues is conveyed by rebound spiking in SPON. • Congenitally deaf mice have imprecise rebound spiking in SPON compared to controls during early postnatal development. • Sequential regulation of ion currents underlying the rebound spiking mechanism rescues a...

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Bibliographic Details
Published in:Neuroscience 2016-11, Vol.337, p.315-330
Main Authors: Leijon, Sara C.M, Peyda, Stefan, Magnusson, Anna K
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Action Potentials - physiology
Animals
Auditory Pathways - growth & development
Auditory Pathways - physiology
Auditory Perception - physiology
brainstem
deaf
h-current
Hearing - physiology
Medicin och hälsovetenskap
Mice
neuritin
Neurology
Neuronal Plasticity
Neurons - physiology
Olivary Nucleus - growth & development
Olivary Nucleus - physiology
Reaction Time - physiology
rebound spiking
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Summary:Highlights • Streaming of temporal acoustic cues is conveyed by rebound spiking in SPON. • Congenitally deaf mice have imprecise rebound spiking in SPON compared to controls during early postnatal development. • Sequential regulation of ion currents underlying the rebound spiking mechanism rescues and normalizes the SPON output. • This stereotyped neuronal compensation could be key for success of auditory prostheses.
ISSN:0306-4522
1873-7544
1873-7544
DOI:10.1016/j.neuroscience.2016.09.014