Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juve...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2016-12, Vol.266 (8), p.771-773
Main Authors: Isaksson, Johan, Grigorenko, Elena L., Oreland, Lars, af Klinteberg, Britt, Koposov, Roman A., Ruchkin, Vladislav
Format: Article
Language:English
Subjects:
Adolescent
Analysis of Variance
Antisocial Personality Disorder - genetics
Conduct disorder
Conduct Disorder - genetics
D beta H
Dopamine beta-Hydroxylase - genetics
Genetic
Genetic Association Studies
Genetic Predisposition to Disease - genetics
Genotype
Humans
Juvenile Delinquency - psychology
Male
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neurosciences
Phenotype
Polymorphism, Single Nucleotide - genetics
Psychiatry
Psychopathy
Russia
Short Communication
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Summary:Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia ( n  = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
ISSN:0940-1334
1433-8491
1433-8491
DOI:10.1007/s00406-015-0664-3