Effect of Nd:YAG laser-assisted non-surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: A short-term pilot study

• Published in: Lasers in surgery and medicine 2016-12, Vol.48 (10), p.929-935
• Main Authors: Javed, Fawad, Kellesarian, Sergio V., Al-Kheraif, Abdulaziz A., Ranna, Vinisha, Qadri, Talat, Yunker, Michael, Malmstrom, Hans, Romanos, Georgios E.
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Biomarkers - blood; Biopsy; Bleeding; Cardiovascular disease; Case-Control Studies; Combined Modality Therapy; Coronary artery; Coronary artery disease; Coronary Artery Disease - complications; Coronary vessels; Demographics; Female; Follow-Up Studies; Heart diseases; Humans; Inflammation; Interleukin-1beta - blood; Interleukins; laser; Lasers; Lasers, Solid-State - therapeutic use; Male; Matrix metalloproteinase; Matrix Metalloproteinase 9 - blood; Medicin och hälsovetenskap; Metalloproteinase; Middle Aged; Neodymium lasers; non-surgical periodontal therapy; Parameters; Patients; Periodontal disease; Periodontal Diseases - blood; Periodontal Diseases - complications; Periodontal Diseases - diagnosis; Periodontal Diseases - therapy; periodontal inflammation; Periodontics; Periodontics - methods; Pilot Projects; Plaque index; Prospective Studies; Semiconductor lasers; Single-Blind Method; Statistical analysis; Subgroups; Surgery; Therapy; Treatment Outcome; YAG lasers
• ISSN: 0196-8092; 1096-9101; 1096-9101
• DOI: 10.1002/lsm.22483

Background/Objective We hypothesized that nonsurgical‐periodontal‐therapy (NSPT) with adjunct Nd:YAG laser therapy is more effective in reducing periodontal inflammatory parameters (plaque index [PI], bleeding‐on‐probing [BOP], and probing‐pocket‐depth [PPD]) and serum interleukin‐1beta (IL‐1β) and matrix metalloproteinase‐9 (MMP‐9) levels in patients with and without coronary artery disease (CAD) than NSPT alone. The aim of this short‐term pilot study was to assess the effect of NSPT + Nd:YAG laser therapy on periodontal parameters and serum IL‐1β and MMP‐9 levels in patients with and without CAD. Study Design A prospective randomized clinical study was conducted on 87 patients who were divided into two groups: Group‐1: 44 patients with CAD and periodontal disease (PD) and Group‐2: 43 patients with PD alone. Treatment‐wise, these individuals were randomly divided into two subgroups: (i) NSPT alone and (ii) NSPT + Nd:YAG laser therapy. Demographic information was collected using a self‐completed questionnaire. Periodontal parameters (PI, BOP, and PPD) and serum IL‐1β and MMP‐9 levels were measured at baseline and after 3 months of treatment. P‐values