Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

• Published in: Journal of ovarian research 2017-03, Vol.10 (1), p.20, Article 20
• Main Authors: Fortner, Renée T, Vitonis, Allison F, Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Weiderpass, Elisabete, Gram, Inger Torhild, Jareid, Mie, Quirós, J Ramón, Duell, Eric J, Sánchez, Maria-Jose, Chirlaque, María Dolores, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Khaw, Kay-Tee, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A, Riboli, Elio, Cramer, Daniel W, Kaaks, Rudolf, Terry, Kathryn L
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigens; Area Under Curve; Biomarkers, Tumor; CA125; CA15.3; Cancer and Oncology; Cancer och onkologi; Case-Control Studies; Clinical medical disciplines: 750; Clinical Medicine; Cohort Studies; Cross-Sectional Studies; Early detection markers; Early Detection of Cancer; Estrogens; Europe - epidemiology; Female; Geriatrics; HE4; Health risk assessment; Humans; Hysterectomy; Klinisk medicin; Klinisk medisinske fag: 750; Medical and Health Sciences; Medical disciplines: 700; Medicin och hälsovetenskap; Medisinske Fag: 700; Menopause; Middle Aged; Oncology: 762; Onkologi: 762; Ovarian cancer; Ovarian Neoplasms - blood; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - therapy; Ovariectomy; Parity; Population Surveillance; Post-menopause; Pregnancy; Risk Factors; Smoking; VDP; Womens health
• ISSN: 1757-2215; 1757-2215
• DOI: 10.1186/s13048-017-0315-6

Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (p  ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p