Correlation between quantitative and semiquantitative parameters in DCE-MRI with a blood pool agent in rectal cancer: can semiquantitative parameters be used as a surrogate for quantitative parameters?

Purpose The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting. Materials and methods Nineteen patients were incl...

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Bibliographic Details
Published in:Abdominal imaging 2017-05, Vol.42 (5), p.1342-1349
Main Authors: Dijkhoff, Rebecca A. P., Maas, Monique, Martens, Milou H., Papanikolaou, Nikolaos, Lambregts, Doenja M. J., Beets, Geerard L., Beets-Tan, Regina G. H.
Format: Article
Language:English
Subjects:
Aged
Biopsy
Chemoradiotherapy
Contrast Media - administration & dosage
Female
Gadolinium - administration & dosage
Gastroenterology
Hepatology
Humans
Image Processing, Computer-Assisted
Imaging
Imaging, Three-Dimensional
Lymphatic Metastasis
Magnetic Resonance Imaging - methods
Male
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neoadjuvant Therapy
Neoplasm Staging
Organometallic Compounds - administration & dosage
Radiology
Rectal Neoplasms - diagnostic imaging
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Retrospective Studies
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Summary:Purpose The aim of this study was to assess correlation between quantitative and semiquantitative parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in rectal cancer patients, both in a primary staging and restaging setting. Materials and methods Nineteen patients were included with DCE-MRI before and/or after neoadjuvant therapy. DCE-MRI was performed with gadofosveset trisodium (Ablavar ® , Lantheus Medical Imaging, North Billerica, Massachusetts, USA). Regions of interest were placed in the tumor and quantitative parameters were extracted with Olea Sphere 2.2 software permeability module using the extended Tofts model. Semiquantitative parameters were calculated on a pixel-by-pixel basis. Spearman rank correlation tests were used for assessment of correlation between parameters. A p value ≤0.05 was considered statistically significant. Results Strong positive correlations were found between mean peak enhancement and mean K trans : 0.79 (all patients, p
ISSN:2366-004X
2366-0058
2366-0058
DOI:10.1007/s00261-016-1024-0