Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10–49 years old: a population-based study from the National Health and Nutrition Examination Survey

We studied the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in younger individuals, age 10–49 years, using samples from the National Health and Nutritional Examination Survey (NHANES) III. NHANES prevalence rates were standardized to the 2000 US total population. Among 12 ...

Full description

Saved in:
Bibliographic Details
Published in:Blood cancer journal (New York) 2017-10, Vol.7 (10), p.e618-e618
Main Authors: Landgren, O, Graubard, B I, Kumar, S, Kyle, R A, Katzmann, J A, Murata, K, Costello, R, Dispenzieri, A, Caporaso, N, Mailankody, S, Korde, N, Hultcrantz, M, Therneau, T M, Larson, D R, Cerhan, J R, Rajkumar, S V
Format: Article
Language:English
Subjects:
631/67/1990/804
692/699/1541/1990/804
Age
Biomedical and Life Sciences
Biomedicine
Cancer Research
Hematology
Hispanic Americans
Medicin och hälsovetenskap
Oncology
Original
original-article
Population-based studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in younger individuals, age 10–49 years, using samples from the National Health and Nutritional Examination Survey (NHANES) III. NHANES prevalence rates were standardized to the 2000 US total population. Among 12 372 individuals (4073 blacks, 4146 Mexican-Americans, 3595 whites, and 558 others), MGUS was identified in 63 persons (0.34%, 95% CI 0.23–0.50). The prevalence of MGUS was significantly higher in blacks (0.88%, 95% CI 0.62–1.26) compared with whites (0.22%, 95% CI 0.11–0.45), P =0.001. The prevalence of MGUS in Mexican-Americans was at an intermediate level (0.41%, 95% CI 0.23–0.73). The disparity in prevalence of MGUS between blacks and whites was most striking in the 40–49 age-group; 3.26% (95% CI 2.04–5.18) versus 0.53% (95% CI 0.20–1.37), P =0.0013. There was a trend to earlier age of onset of MGUS in blacks compared with whites. MGUS was seen in only two persons in the 10–19 age-group (both Mexican-American), and in three persons in the 20–29-year age-group (all of whom were black). In persons less than 50 years of age, MGUS is significantly more prevalent, with up to 10 years earlier age of onset, in blacks compared with whites.
ISSN:2044-5385
2044-5385
DOI:10.1038/bcj.2017.97