Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34 years longitudinal data from the Stockholm–Gotland cancer registry

Rationale Survival after loco-regional failure (LRF) of breast cancer was investigated at the population level. Methods Using the Stockholm cancer registry, 2698 patients diagnosed with LRF between 1980 and 2014 were identified and divided into three cohorts by year of LRF diagnosis. Post-relapse ev...

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Bibliographic Details
Published in:Breast cancer research and treatment 2018-12, Vol.172 (3), p.703-712
Main Authors: Falato, Claudette, Taylor, Sara K., Szulkin, Robert, Nordblom, Axel, Eriksson, Louise, Sofiadis, Anastasios, Fredriksson, Irma, Hartman, Johan, Bergh, Jonas, Foukakis, Theodoros
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Breast cancer
Breast Neoplasms - mortality
Cancer research
Epidemiology
Female
Health risk assessment
Humans
Longitudinal Studies
Medical diagnosis
Medical prognosis
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Middle Aged
Mortality
Neoplasm Recurrence, Local - mortality
Oncology
Prognosis
Registries
Regression analysis
Statistical analysis
Survival
Tumors
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Summary:Rationale Survival after loco-regional failure (LRF) of breast cancer was investigated at the population level. Methods Using the Stockholm cancer registry, 2698 patients diagnosed with LRF between 1980 and 2014 were identified and divided into three cohorts by year of LRF diagnosis. Post-relapse event-free survival (EFS) and overall survival (OS) were analyzed separately in local and loco-regional relapses and compared across the cohorts by Kaplan–Meier method. Relative survival was estimated and Poisson regression models, adjusted for clinically relevant prognostic factors, were fitted for excess mortality ratio calculation. Age-related survival trends were also explored. Results Among 1922 patients diagnosed with local relapse, 1032 (54%) EFS events and 931 (48%) deaths were registered. A significant improvement in EFS ( p  
ISSN:0167-6806
1573-7217
1573-7217
DOI:10.1007/s10549-018-4936-2