Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer

Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transfor...

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Published in:Head & neck 2019-02, Vol.41 (2), p.309-314
Main Authors: Pakkanen, Pihla P., Aaltonen, Leena‐Maija, Sorsa, Timo A., Tervahartiala, Taina I., Hagström, Jaana K., Ilmarinen, Taru T.
Format: Article
Language:English
Subjects:
biomarkers
Cell survival
Head and neck
Human papillomavirus
Laryngeal cancer
laryngeal carcinoma
Matrix metalloproteinase
Medical prognosis
Medicin och hälsovetenskap
Metalloproteinase
MMP‐8
Neutrophil collagenase
Papilloma
recurrent respiratory papilloma
Squamous cell carcinoma
TIMP‐1
Tissue inhibitor of metalloproteinase 1
Tumors
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Summary:Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP. Methods We analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow‐up. Results Elevated S‐MMP‐8 level in RRP was associated with malignant transformation (P = .01). Compared to patients with RRP, S‐MMP‐8 in patients with LSCC was significantly higher (P 
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.25459