KID-1, a Protein Kinase Induced by Depolarization in Brain

Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 ( k inase i nduced by d epolarization), that is induced by membrane depolarization or forskolin, but not...

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Bibliographic Details
Published in:The Journal of biological chemistry 1998-06, Vol.273 (26), p.16535-16543
Main Authors: Feldman, J D, Vician, L, Crispino, M, Tocco, G, Marcheselli, V L, Bazan, N G, Baudry, M, Herschman, H R
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain - enzymology
Catalysis
Colforsin - pharmacology
Enzyme Induction
Gene Expression Regulation
Genes, Immediate-Early
Growth Substances - pharmacology
Histones - metabolism
Medicin och hälsovetenskap
Membrane Potentials - physiology
Molecular Sequence Data
Neuronal Plasticity - physiology
PC12 Cells
Phosphorylation
Protein-Serine-Threonine Kinases - biosynthesis
Protein-Serine-Threonine Kinases - chemistry
Protein-Serine-Threonine Kinases - genetics
Proto-Oncogene Proteins - chemistry
Proto-Oncogene Proteins c-pim-1
Rats
Recombinant Fusion Proteins - metabolism
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Summary:Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 ( k inase i nduced by d epolarization), that is induced by membrane depolarization or forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. KID-1 is an immediate early gene that shares a high degree of sequence similarity with the family of PIM-1 serine/threonine protein kinases. Recombinant KID-1 fusion protein is able to catalyze both histone phosphorylation and autophosphorylation. KID-1 mRNA is present in a number of unstimulated tissues, including brain. In response to kainic acid and electroconvulsive shock-induced seizures, KID-1 is induced in specific regions of the hippocampus and cortex.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.273.26.16535