Management of MDS with Isolated Del(5q) Patients in the European MDS (EUMDS) Registry, a Unique Prospective Real-World Dataset

• Published in: Blood 2021-11, Vol.138 (Supplement 1), p.4671-4671
• Main Authors: Bowen, David, Taylor, Adele, Fenaux, Pierre, Guerci-Bresler, Agnes, Itzykson, Raphael, Symeonidis, Argiris, Kotsianidis, Ioannis, Mittelman, Moshe, Sanz, Guillermo, Culligan, Dominic J., Cermak, Jaroslav, Stauder, Reinhard, Hellstrom Lindberg, Eva, Malcovati, Luca, Langemeijer, Saskia M.C., Germing, Ulrich, Oster, Howard S., Madry, Krzysztof, Skov Holm, Mette, Smith, Alexandra, van Marrewijk, Corine, de Witte, Theo M
• Format: Article
• Language: English
• Subjects: Medicin och hälsovetenskap
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood-2021-150322

'MDS with isolated del(5q)' is a subtype of Myelodysplastic Syndrome (MDS) with characteristic morphological and genomic features. Clinically, MDS with isolated del(5q) is uniquely responsive to immunomodulatory agents, with lenalidomide (LEN) approved for treating anemia in this indication. Erythropoiesis Stimulating Agents (ESA) and red cell transfusion (RBCT) are other options for anemia management. The EUMDS Registry is an international prospective registry of newly diagnosed patients (within 100 days of diagnosis) with IPSS Low/Int-1-risk MDS (plus higher-risk MDS from 2017) recruiting since 1 st April 2008, currently at 146 sites in 17 countries. We describe the largest prospective Registry series of 'MDS with del(5q)' patients, with data from diagnosis. Methods Comparative analyses of baseline characteristics for categorical variables compared different groups by chi 2 test, and for continuous variables by Kruskal-Wallis test. p values are given with Bonferonni correction applied. Results Baseline characteristics Of 2469 EUMDS patients, 197 (8%) met the WHO 2016 classification criteria for 'MDS with isolated del5q'. Median follow up is 4.3 yrs. 77% were female (34% for all EUMDS patients), and median age was 73y. In comparison to EUMDS patients lacking del(5q), patients with MDS with isolated del(5q) were lower risk at diagnosis (IPSS and IPSS-R, p