HPV Type Distribution in Benign, High-Grade Squamous Intraepithelial Lesions and Squamous Cell Cancers of the Anus by HIV Status

The incidence of anal cancer is increasing, especially in high-risk groups, such as PLWH. HPV 16, a high-risk (HR) HPV genotype, is the most common genotype in anal high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) in the general population. However, few studies ha...

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Bibliographic Details
Published in:Cancers 2023, Vol.15 (3), p.660
Main Authors: Chowdhury, Sona, Darragh, Teresa M, Berry-Lawhorn, J Michael, Isaguliants, Maria G, Vonsky, Maxim S, Hilton, Joan F, Lazar, Ann A, Palefsky, Joel M
Format: Article
Language:English
Subjects:
Anal cancer
Anus
Benign
Cancer
Carcinogens
Colorectal cancer
Complications and side effects
Confidence intervals
Cytology
Gene amplification
Genotypes
Genotyping
HIV
HIV infection
Human immunodeficiency virus
Human papillomavirus
Hybridization
Immune system
Infections
Lesions
Medical screening
Medicin och hälsovetenskap
Papillomavirus infections
Population studies
Risk factors
Risk groups
Squamous cell carcinoma
Womens health
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Summary:The incidence of anal cancer is increasing, especially in high-risk groups, such as PLWH. HPV 16, a high-risk (HR) HPV genotype, is the most common genotype in anal high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) in the general population. However, few studies have described the distribution of HR HPV genotypes other than HPV 16 in the anus of PLWH. HPV genotyping was performed by DNA amplification followed by dot-blot hybridization to identify the HR and low-risk (LR) genotypes in benign anal lesions (n = 34), HSIL (n = 30), and SCC (n = 51) of PLWH and HIV-negative individuals. HPV 16 was the most prominent HR HPV identified, but it was less common in HSIL and SCC from PLWH compared with HIV-negative individuals, and other non-HPV 16 HR HPV (non-16 HR HPV) types were more prevalent in samples from PLWH. A higher proportion of clinically normal tissues from PLWH were positive for one or more HPV genotypes. Multiple HPV infection was a hallmark feature for all tissues (benign, HSIL, SCC) of PLWH. These results indicate that the development of anal screening approaches based on HPV DNA testing need to include non-16 HR HPVs along with HPV 16, especially for PLWH. Along with anal cytology, these updated screening approaches may help to identify and prevent anal disease progression in PLWH.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15030660