TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours

Purpose Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-termin...

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Bibliographic Details
Published in:Pituitary 2023-04, Vol.26 (2), p.227-236
Main Authors: Kolnes, Anders Jensen, Øystese, Kristin Astrid Berland, Sjöstedt, Evelina, Olarescu, Nicoleta Cristina, Heck, Ansgar, Pahnke, Jens, Dahlberg, Daniel, Berg-Johnsen, Jon, Ringstad, Geir, Casar-Borota, Olivera, Bollerslev, Jens, Jørgensen, Anders Palmstrøm
Format: Article
Language:English
Subjects:
Animals
Endocrinology
Follicle Stimulating Hormone
Gonadotrophs - metabolism
Gonadotropins
Growth factors
Human Physiology
Inhibin
Luteinizing hormone
Male
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Membrane proteins
Mice
Neuroendocrine Tumors
Pituitary
Pituitary (anterior)
Pituitary adenomas
Pituitary Neoplasms - pathology
Plasma gonadotropins
Transforming growth factor beta receptor 3 (TGFBR3)
Transforming growth factor beta receptor 3 like (TGFBR3L)
Transforming Growth Factors - metabolism
Tumour volume
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Summary:Purpose Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-terminal region. We aimed to characterize TGFBR3L detection in a well-characterized, prospectively collected cohort of non-functioning pituitary neuroendocrine tumours (NF-PitNETs) and correlate it to clinical data. Methods 144 patients operated for clinically NF-PitNETs were included. Clinical, radiological and biochemical data were recorded. Immunohistochemical (IHC) staining for FSHβ and LHβ was scored using the immunoreactive score (IRS), TGFBR3L and TGFBR3 were scored by the percentage of positive stained cells. Results TGFBR3L staining was selectively present in 52% of gonadotroph tumours. TGFBR3L was associated to IRS of LHβ (median 2 [IQR 0–3] in TGFBR3L negative and median 6 [IQR 3–9] in TGFBR3L positive tumours, p 
ISSN:1386-341X
1573-7403
1573-7403
DOI:10.1007/s11102-023-01310-x