Resting-state functional connectivity in Autoimmune Addison's Disease

Patients with autoimmune Addison’s disease (AAD) are unable to produce glucocorticoids (GCs), mineralocorticoids (MCs) and androgens from the adrenal cortex and therefore require life-long treatment with GCs and MCs. Due to the sensitivity of the brain to cortisol and androgens, brain function might...

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Published in:PSYCHONEUROENDOCRINOLOGY 2023-07, Vol.153, p.106206, Article 106206
Main Authors: van't Westeinde, Annelies, Padilla, Nelly, Lajic, Svetlana
Format: Article
Language:English
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Medicin och hälsovetenskap
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Summary:Patients with autoimmune Addison’s disease (AAD) are unable to produce glucocorticoids (GCs), mineralocorticoids (MCs) and androgens from the adrenal cortex and therefore require life-long treatment with GCs and MCs. Due to the sensitivity of the brain to cortisol and androgens, brain function might be affected in patients, as the replacement regime cannot mimic the natural rhythmicity of hormonal secretion. Alterations in brain function might predispose to cognitive or mood disturbances. The present study investigated resting-state functional connectivity (rs-fc) in patients with AAD. Resting-state fMRI data was collected from 57 (33 females) patients with AAD and 69 (39 females) control participants, aged 19-43 years. Resting-state brain networks were identified with independent component analysis (FSL MELODIC). Dual-regression analysis was applied to test for group differences in rs-fc in these networks. Within the patient group we tested the association between rs-fc and glucocorticoid replacement dose in mg/m2/day. Significant clusters were identified with threshold free cluster enhancement and considered to be significant at p
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2023.106206