Platelet serotonin functions in untreated major depression

The uptake of [ 14C]5-HT, [ 3H]paroxetine and [ 3H]LSD binding was determined in platelets from 30 untreated patients with major depression and compared with corresponding variables from 30 healthy age-, sex- and season-matched control subjects. The maximum velocity ( V max) for the 5-HT uptake was...

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Bibliographic Details
Published in:Psychiatry research 1999-02, Vol.85 (2), p.189-198
Main Authors: Neuger, Jolanta, El Khoury, A, Kjellman, Bengt F, Wahlund, Bjorn, Åberg-Wistedt, Anna, Stain-Malmgren, Rigmor
Format: Article
Language:English
Subjects:
5-HT 2 receptors
Adult
Adult and adolescent clinical studies
Aged
Analysis of Variance
Anxiety
Biological and medical sciences
Blood Platelets - physiology
Depression
Depressive Disorder, Major - physiopathology
Female
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Mood disorders
Paroxetine binding sites
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Serotonin - physiology
Regression Analysis
Serotonin - blood
Serotonin - deficiency
Serotonin uptake
Severity of Illness Index
Sex Factors
Suicide
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Summary:The uptake of [ 14C]5-HT, [ 3H]paroxetine and [ 3H]LSD binding was determined in platelets from 30 untreated patients with major depression and compared with corresponding variables from 30 healthy age-, sex- and season-matched control subjects. The maximum velocity ( V max) for the 5-HT uptake was significantly decreased in patients ( P=0.014) compared to control subjects. Depressed women had significantly lower V max than female control subjects. In men, V max did not differ between patients and control subjects. V max was significantly lower in male inpatients compared with male outpatients ( P=0.05). The density ( B max) of 5-HT uptake sites was found to be significantly increased in patients ( P
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(99)00006-2