Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy: population-based cohort study

• Published in: BJS open 2024, Vol.8 (3)
• Main Authors: Östrand, Emil, Rystedt, Jenny, Engstrand, Jennie, Frühling, Petter, Hemmingsson, Oskar, Sandström, Per, Sternby Eilard, Malin, Tingstedt, Bobby, Buchwald, Pamela
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Clinical Medicine; Cohort Studies; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Female; Hepatectomy; Humans; Kirurgi; Klinisk medicin; Liver Neoplasms - drug therapy; Liver Neoplasms - mortality; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Male; Margins of Excision; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Original; Proportional Hazards Models; Registries; Surgery; Sweden - epidemiology
• ISSN: 2474-9842; 2474-9842
• DOI: 10.1093/bjsopen/zrae035

Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and ≥1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model. A total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin