Recurrences after nephron-sparing treatments of renal cell carcinoma: a competing risk analysis

• Published in: World journal of urology 2024-08, Vol.42 (1), p.474, Article 474
• Main Authors: Rosenblad, Andreas Karlsson, Hashim, Bassam Mazin, Lindblad, Per, Ljungberg, Börje
• Format: Article
• Language: English
• Subjects: Ablation Techniques - methods; Ablative therapy; Aged; Carcinoma, Renal Cell - surgery; Carcinoma, Renal Cell - therapy; Death; Distant metastatic recurrence; Female; Humans; Kidney cancer; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Kidney Neoplasms - therapy; Local recurrence; Male; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Metastases; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Nephrectomy; Nephrectomy - methods; Nephrology; Nephrons; Oncology; Organ Sparing Treatments; Partial nephrectomy; Regression analysis; Renal cell carcinoma; Risk Assessment; Sweden - epidemiology; Tumors; Urology
• ISSN: 1433-8726; 0724-4983; 1433-8726
• DOI: 10.1007/s00345-024-05172-1

Purpose To examine associations between ablative therapy (AT) and partial nephrectomy (PN) and the occurrence of local recurrence (LR), distant metastatic recurrence (DMR) and all-cause mortality in a nation-wide real-world population-based cohort of patients with nonmetastatic renal cell carcinoma (nmRCC). Methods Data on 2751 AT- or PN-treated nmRCC tumours diagnosed during 2005–2018, representing 2701 unique patients, were obtained from the National Swedish Kidney Cancer Register. Time to LR/DMR or death with/without LR/DMR was analysed using Cox regression models. Results During a mean of 4.8 years follow-up, LR was observed for 111 (4.0%) tumours, DMR for 108 (3.9%) tumours, and death without LR/DMR for 206 (7.5%) tumours. AT-treated tumours had a 4.31 times higher risk of LR (P