Analysis of pilocytic astrocytoma by comparative genomic hybridization

Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed ab...

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Bibliographic Details
Published in:British journal of cancer 2000-03, Vol.82 (6), p.1218-1222
Main Authors: Sanoudou, D, Tingby, O, Ferguson-Smith, M A, Collins, V P, Coleman, N
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Astrocytoma - genetics
Astrocytoma - physiopathology
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - physiopathology
Cancer Research
Child
Child, Preschool
Chromosome Aberrations - genetics
Chromosomes
Drug Resistance
Epidemiology
Female
Gene Duplication
Histopathology
Humans
Hybridization
Infant
Infant, Newborn
Male
Medical research
Medical sciences
Medicin och hälsovetenskap
Molecular Medicine
Mutation
Neurology
Nucleic Acid Hybridization
Oncology
Pediatrics
Short Communication
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed abnormalities detectable by comparative genomic hybridization, and in each case this represented gain of a single chromosome. Interestingly, two of seven tumours from adults showed abnormalities, which were multiple and relatively complex. Six of the seven tumours showing abnormalities were from female patients (two adults and four children). The most frequently detectable abnormality was gain of 9q34.1-qter, which was present in three cases (two adult and one paediatric). © 2000 Cancer Research Campaign
ISSN:0007-0920
1532-1827
DOI:10.1054/bjoc.1999.1066