EXPRESSION OF HEAT SHOCK PROTEINS IN HEAVY METAL-PROVOKED INFLAMED HUMAN SKIN

ABSTRACT The expression of heat shock protein (hsp) 65, 72 and 90 was studied in human inflamed skin after heavy metal salt treatment, by using epicutaneous patch-testing procedure and immunohistochemistry. There was a slight immunoreactivity to hsp 65 and hsp 72, but not to hsp 90 in keratinocytes...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2002-01, Vol.24 (3), p.383-394
Main Author: Nordlind, K.
Format: Article
Language:English
Subjects:
Bacterial Proteins
Biological and medical sciences
Chaperonin 60
Chaperonins - biosynthesis
Chemical and industrial products toxicology. Toxic occupational diseases
Heat shock proteins
Heat-Shock Proteins - biosynthesis
Hepatitis - metabolism
HSP72 Heat-Shock Proteins
HSP90 Heat-Shock Proteins - biosynthesis
Humans
Inflammation
Keratinocytes - drug effects
Keratinocytes - metabolism
Medical sciences
Medicin och hälsovetenskap
Metal salts
Metals - toxicity
Metals and various inorganic compounds
Skin - drug effects
Skin - metabolism
Skin-human
Toxicology
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Summary:ABSTRACT The expression of heat shock protein (hsp) 65, 72 and 90 was studied in human inflamed skin after heavy metal salt treatment, by using epicutaneous patch-testing procedure and immunohistochemistry. There was a slight immunoreactivity to hsp 65 and hsp 72, but not to hsp 90 in keratinocytes in normal skin. An increased immunoreactivity to hsp 72 was obtained in apically located keratinocytes in a statistically signific ant (p
ISSN:0892-3973
1532-2513
DOI:10.1081/IPH-120014724