Influence of Chronic Fluorosis on Membrane Lipids in Rat Brain

Brain membrane lipid in rats were analyzed after being fed either 30 or 100 ppm fluoride for 3, 5, and 7 months. The protein content of brain with fluorosis decreased, whereas the DNA content remained stable during the entire period of investigation. After 7 months of fluoride treatment, the total b...

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Bibliographic Details
Published in:Neurotoxicology and teratology 1998-09, Vol.20 (5), p.537-542
Main Authors: Guan, Zhi-Zhong, Wang, Ya-Nan, Xiao, Kai-Qi, Dai, Da-Ying, Chen, Yuan-Hua, Liu, Jia-Liu, Sindelar, Pavel, Dallner, Gustav
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain
Brain - drug effects
Brain - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
Fatty acid
Fluorides, Topical - toxicity
Fluorosis
Medical sciences
Medicin och hälsovetenskap
Membrane Lipids - metabolism
Metals and various inorganic compounds
Neutral lipid
Phosphatidylcholines - metabolism
Phosphatidylethanolamines - metabolism
Phosphatidylserines - metabolism
Phospholipid
Phospholipids - metabolism
Rats
Rats, Wistar
Sodium Fluoride - toxicity
Toxicology
Ubiquinone - metabolism
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Summary:Brain membrane lipid in rats were analyzed after being fed either 30 or 100 ppm fluoride for 3, 5, and 7 months. The protein content of brain with fluorosis decreased, whereas the DNA content remained stable during the entire period of investigation. After 7 months of fluoride treatment, the total brain phospholipid content decreased by 10% and 20% in the 30 and 100 ppm fluoride groups, respectively. The main species of phospholipid influenced by fluorosis were phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine. The fatty acid and aldehyde compositions of individual phospholipid classes were unchanged. No modifications could be detected in the amounts of cholesterol and dolichol. After 3 months of fluoride treatment, ubiquinone contents in brain were lower; however, at 7 months they were obviously increased in both groups of fluoride treatment. The results demonstrate that the contents of phospholipid and ubiquinone are modified in brains affected by chronic fluorosis and these changes of membrane lipids could be involved in the pathogenesis of this disease.
ISSN:0892-0362
1872-9738
DOI:10.1016/S0892-0362(97)00136-0