Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal system

Serum lipoproteins and cardiovascular risk are affected by endogenous and exogenous sex hormones. As part of a multicenter evaluation of a permeation-enhanced testosterone transdermal system (TTD), the interrelationships among serum lipoproteins, hormone levels, anthropometric parameters, and age we...

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Published in:The journal of clinical endocrinology and metabolism 2001-03, Vol.86 (3), p.1026-1033
Main Authors: DOBS, Adrian S, BACHORIK, Paul S, ARVER, Stefan, MEIKLE, A. Wayne, SANDERS, Steven W, CARAMELLI, Kim E, MAZER, Norman A
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adult
Aged
Aging
Anthropometry
Biological and medical sciences
Cholesterol - blood
Dihydrotestosterone - blood
Estradiol - blood
Genital system. Reproduction
Gonadal Steroid Hormones - blood
Humans
Hypogonadism - drug therapy
Hypogonadism - physiopathology
Lipoproteins - blood
Lipoproteins, HDL - blood
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Pharmacology. Drug treatments
Sex Hormone-Binding Globulin - analysis
Testosterone - administration & dosage
Testosterone - blood
Testosterone - therapeutic use
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Summary:Serum lipoproteins and cardiovascular risk are affected by endogenous and exogenous sex hormones. As part of a multicenter evaluation of a permeation-enhanced testosterone transdermal system (TTD), the interrelationships among serum lipoproteins, hormone levels, anthropometric parameters, and age were investigated in 29 hypogonadal men. Subjects (aged 21-65 yr) were first studied during prior treatment with im testosterone esters (IM-T), then during an 8-week period of androgen withdrawal resulting in a hypogonadal state (HG), and finally during a 1-yr treatment period with the TTD. Compared with treatment with IM-T, the HG period produced increases in high density lipoprotein [HDL; 12.0 +/- 1.6% (+/-SEM); P
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.86.3.1026