Retrospective analysis of the efficacy of cefotaxime sodium dosed twice daily: The Swedish experience

In a Swedish multicenter, comparative, retrospective study, patients with different types of infections—bacteremia-septicemia, genitourinary, intra-abdominal, central nervous system, and lower respiratory tract infections—were randomly selected from the hospital records. Patients treated with cefota...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1995-05, Vol.22 (1), p.163-166
Main Authors: Bergquist, S.-O., Eriksson, I., Eriksson, S., Lönnbro, N., Runehagen, A., Styrud, J., Ahlquist, G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Bacterial Infections - physiopathology
Biological and medical sciences
Cefotaxime - administration & dosage
Cefotaxime - therapeutic use
Cephalosporins - administration & dosage
Cephalosporins - therapeutic use
Child
Child, Preschool
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Pharmacology. Drug treatments
Retrospective Studies
Sweden
Treatment Outcome
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Summary:In a Swedish multicenter, comparative, retrospective study, patients with different types of infections—bacteremia-septicemia, genitourinary, intra-abdominal, central nervous system, and lower respiratory tract infections—were randomly selected from the hospital records. Patients treated with cefotaxime twice or three times a day as monotherapy (excluding metronidazole) for at least 1 day (240 cases) were analyzed in terms of clinical and bacteriologic outcome, these results were correlated wiih the dosing regimen. Similarly high success rates (cure and improvement) at hospital discharge were observed in both group initially treated with cefotaxime 1 g twice daily and 2 g twice daily (97 and 96%, respectively). A total of 73% of patients were initially treated with cefotaxime for only 3 days at most before changing to a lower dose regimen, an alternate intravenous treatment, or oral drug follow-up. Clinical evaluation at hospital discharge revealed a clinical success rate between 87 and 100%, depending on the type of infection.
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(95)00087-Q