Uncoupling proteins in human heart

Abnormal energetic activity in heart failure correlates inversely with plasma free-fatty-acid concentrations. However, the link between energetic and metabolic abnormalities is unknown. To investigate this association, we obtained blood samples from 39 patients undergoing coronary artery bypass graf...

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Bibliographic Details
Published in:The Lancet (British edition) 2004-11, Vol.364 (9447), p.1786-1788
Main Authors: Murray, Andrew J, Anderson, Russell E, Watson, Gillian C, Radda, George K, Clarke, Kieran
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Alternative energy sources
ATP
Blood
Carrier Proteins - metabolism
Energy Metabolism
Fatty acids
Fatty Acids, Nonesterified - blood
Female
Glucose Transporter Type 4
Heart failure
Heart Failure - metabolism
Heart Failure - physiopathology
Humans
Ion Channels
Male
Medical research
Medical treatment
Medicin och hälsovetenskap
Membrane Transport Proteins - metabolism
Middle Aged
Mitochondria, Heart - metabolism
Mitochondrial Proteins - metabolism
Monosaccharide Transport Proteins - metabolism
Muscle Proteins - metabolism
Muscle, Skeletal - metabolism
Myocardium - metabolism
Proteins
Surgery
Uncoupling Agents - metabolism
Uncoupling Protein 2
Uncoupling Protein 3
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Summary:Abnormal energetic activity in heart failure correlates inversely with plasma free-fatty-acid concentrations. However, the link between energetic and metabolic abnormalities is unknown. To investigate this association, we obtained blood samples from 39 patients undergoing coronary artery bypass graft surgery. Patients fasted overnight before samples were taken. When plasma free-fatty-acid concentrations were raised, cardiac mitochondrial uncoupling proteins (UCP) increased (isoform UCP2, p
ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(04)17402-3