Use of Inflammatory Markers for Early Detection of Bacteraemia in Patients with Febrile Neutropenia

The aim of the study was to evaluate the ability of procalcitonin, C-reactive protein, serum amyloid A, interleukin-6 and interleukin-8 to predict bacteraemia during the 2 first d of fever in neutropenic patients. A total of 94 febrile neutropenic episodes in 60 patients were studied. Plasma samples...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2004-05, Vol.36 (5), p.365-371
Main Authors: Persson, Lennart, Engervall, Per, Magnuson, Anders, Vikerfors, Tomas, Söderquist, Bo, Hansson, Lars-olof, Tidefelt, Ulf
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Amyloid - analysis
Analysis of Variance
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Bacteremia - diagnosis
Bacteremia - etiology
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
C-Reactive Protein - analysis
Calcitonin - analysis
Calcitonin Gene-Related Peptide
Cohort Studies
Female
Fever - diagnosis
Fever - etiology
Hematologic and hematopoietic diseases
Hematologic Neoplasms - diagnosis
Hematologic Neoplasms - drug therapy
Human bacterial diseases
Humans
Infectious diseases
Inflammation Mediators - analysis
Interleukin-6 - analysis
Interleukin-8 - analysis
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Neutropenia - diagnosis
Neutropenia - etiology
Other diseases. Hematologic involvement in other diseases
Probability
Prognosis
Protein Precursors - analysis
Sensitivity and Specificity
Severity of Illness Index
Staphylococcus
Statistics, Nonparametric
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Summary:The aim of the study was to evaluate the ability of procalcitonin, C-reactive protein, serum amyloid A, interleukin-6 and interleukin-8 to predict bacteraemia during the 2 first d of fever in neutropenic patients. A total of 94 febrile neutropenic episodes in 60 patients were studied. Plasma samples were analysed at 10-h intervals from the onset of fever. Clinical events were categorized into 4 groups: 1) bacteraemia caused by other agents than coagulase-negative staphylococci (non-CNS bacteraemia) (n=21), 2) coagulase-negative staphylococci bacteraemia (n=15), 3) microbiologically or clinically documented infection without bacteraemia (n=26) and 4) fever of unknown origin (n=32). In non-CNS bacteraemia all markers, except for serum amyloid A, showed significantly higher levels compared to patients with fever of unknown origin (p
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540410020217