Metabolic fates in humans of linamarin in cassava flour ingested as stiff porridge

Insufficiently processed products from cassava roots may contain residual amounts of cyanogenic glucosides, mainly linamarin. The fate of orally ingested linamarin was studied following a meal of cassava porridge prepared from cassava flour from southern Tanzania with 82 mg cyanide equivalents (3035...

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Bibliographic Details
Published in:Food and chemical toxicology 1999-04, Vol.37 (4), p.307-312
Main Authors: Carlsson, L, Mlingi, N, Juma, A, Ronquist, G, Rosling, H
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
cassava roots
cyanide
cyanogen compounds
detoxification
Female
Food toxicology
Humans
Inactivation, Metabolic
linamarin
Male
Manihot
Manihot - chemistry
Medical sciences
Medicin och hälsovetenskap
Nitriles - blood
Nitriles - metabolism
Nitriles - urine
Plant Roots - chemistry
Tanzania
thiocyanate
Thiocyanates - metabolism
Toxicology
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Summary:Insufficiently processed products from cassava roots may contain residual amounts of cyanogenic glucosides, mainly linamarin. The fate of orally ingested linamarin was studied following a meal of cassava porridge prepared from cassava flour from southern Tanzania with 82 mg cyanide equivalents (3035 μmol) of linamarin per kg dry weight. Following ingestion of amounts of porridge containing 243–571 μmol linamarin by 15 healthy adults a mean (range) of 21% (1–47%) of the linamarin ingested was excreted in the urine within 24 hours and a mean of 1% in the next 24 hours. Serum thiocyanate, the main cyanide metabolite, increased in all subjects from a mean (± SD) of 34±26 to 78±28 μmol/litre ( P
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(99)00015-0