Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia

• Published in: Brain communications 2023, Vol.5 (5), p.fcad264-fcad264
• Main Authors: Harper, Luke, de Boer, Sterre, Lindberg, Olof, Lätt, Jimmy, Cullen, Nicholas, Clark, Lyles, Irwin, David, Massimo, Lauren, Grossman, Murray, Hansson, Oskar, Pijnenburg, Yolande, McMillan, Corey T, Santillo, Alexander F
• Format: Article
• Language: English
• Subjects: Basic Medicine; brain reserve; cingulate; frontotemporal dementia; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Neurosciences; Neurovetenskaper; Original; paracingulate; sulcation
• ISSN: 2632-1297; 2632-1297
• DOI: 10.1093/braincomms/fcad264

Abstract Frontotemporal dementia is the second most common form of early onset dementia ( 0.41, P = 0.02. Education was not associated with age at onset (β = −0.05, P = 0.75). The presence of a right paracingulate sulcus was associated with an 83% increased risk of death per year after age at onset (hazard ratio 1.83, confidence interval [1.09–3.07], P < 0.02), whilst the mean age at death was similar for individuals with a present and absent right paracingulate sulcus (P = 0.7). Right paracingulate sulcal presence was not associated with baseline cortical thickness. Right paracingulate sulcal presence is associated with disease expression and survival in sporadic behavioural variant frontotemporal dementia. Findings provide evidence of neurodevelopmental brain reserve in behavioural variant frontotemporal dementia that may be important in the design of trials for future therapeutic approaches. Harper et al. report an association between right paracingu