Mapping of quantitative trait loci for life history traits segregating within common frog populations

The evolution of complex traits is often shaped by adaptive divergence. However, very little is known about the number, effect size, and location of the genomic regions influencing the variation of these traits in natural populations. Based on a dense linkage map of the common frog, Rana temporaria,...

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Bibliographic Details
Published in:Heredity 2019-06, Vol.122 (6), p.800-808
Main Authors: Palomar, Gemma, Vasemägi, Anti, Ahmad, Freed, Nicieza, Alfredo G, Cano, José Manuel
Format: Article
Language:English
Subjects:
Amphibians
Animals
Body Size
Chromosome Mapping
Divergence
Evolutionary Biology
Evolutionsbiologi
Female
Fitness
Frogs
Gene mapping
Genetic diversity
Genomics
Growth rate
Life history
Life History Traits
Male
Mapping
Metabolic rate
Metamorphosis
Metamorphosis, Biological
Natural populations
Phenotypic variations
Population studies
Populations
Quantitative Trait Loci
Rana temporaria
Rana temporaria - genetics
Rana temporaria - growth & development
Reproductive fitness
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Summary:The evolution of complex traits is often shaped by adaptive divergence. However, very little is known about the number, effect size, and location of the genomic regions influencing the variation of these traits in natural populations. Based on a dense linkage map of the common frog, Rana temporaria, we have localized, for the first time in amphibians, three significant and nine suggestive quantitative trait loci (QTLs) for metabolic rate, growth rate, development time, and weight at metamorphosis, explaining 5.6-18.9% of the overall phenotypic variation in each trait. We also found a potential pleiotropic QTL between development time and size at metamorphosis that, if confirmed, might underlie the previously reported genetic correlation between these traits. Furthermore, we demonstrate that the genetic variation linked to fitness-related larval traits segregates within Rana temporaria populations. This study provides the first insight into the genomic regions that affect larval life history traits in anurans, providing a valuable resource to delve further into the genomic basis of evolutionary change in amphibians.
ISSN:0018-067X
1365-2540
1365-2540
DOI:10.1038/s41437-018-0175-x