Genome-wide association study identifies loci influencing natural antibody titers in milk of Dutch Holstein-Friesian cattle

Natural antibodies (NAb) are produced without any antigenic stimulation as a part of the innate immune system and provide a first line of defense against pathogens. Hence, they may be a useful trait when estimating an animal's potential immune competence and in selection for disease resistance....

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Bibliographic Details
Published in:Journal of dairy science 2019-12, Vol.102 (12), p.11092-11103
Main Authors: Cordero-Solorzano, Juan, Parmentier, Henk K., Arts, Joop A.J., van der Poel, Jan, de Koning, Dirk Jan, Bovenhuis, Henk
Format: Article
Language:English
Subjects:
Animal and Dairy Science
Animals
Antibodies - analysis
Antibodies - genetics
Cattle - immunology
Chromosomes
dairy cattle
Female
genome-wide association study
Genome-Wide Association Study - veterinary
Genotype
Hemocyanins - immunology
Husdjursvetenskap
immunoglobulin
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Lactation
Lipopolysaccharides - immunology
Milk - immunology
natural antibody
Phenotype
Quantitative Trait Loci
Teichoic Acids - immunology
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Summary:Natural antibodies (NAb) are produced without any antigenic stimulation as a part of the innate immune system and provide a first line of defense against pathogens. Hence, they may be a useful trait when estimating an animal's potential immune competence and in selection for disease resistance. The aim of this study was to identify genomic regions associated with different NAb traits in milk and potentially describe candidate genes. Milk samples from 1,695 first-lactation Holstein Friesian cows with titer measurements for keyhole limpet hemocyanin, lipopolysaccharide, lipoteichoic acid, and peptidoglycan-binding total NAb and isotypes IgG1, IgM, and IgA were used. Genome-wide association study analyses were performed using imputed 777K SNP genotypes, accounting for relationships using pedigree information. Functional enrichment analysis was performed on the significantly associated genomic regions to look for candidate genes. For IgM NAb, significant associations (false discovery rate
ISSN:0022-0302
1525-3198
1525-3198
DOI:10.3168/jds.2019-16627