Diverse plant viruses: a toolbox for dissection of cellular pathways

Research in virology has usually focused on one selected host-virus pathosystem to examine the mechanisms underlying a particular disease. However, as exemplified by the mechanistically versatile suppression of antiviral RNA silencing by plant viruses, there may be functionally convergent evolution....

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Bibliographic Details
Published in:Journal of experimental botany 2019-06, Vol.70 (12), p.3029-3034
Main Authors: Shukla, Aayushi, López-González, Silvia, Hoffmann, Gesa, Hafrén, Anders
Format: Article
Language:English
Subjects:
Botanik
Botany
Host-Pathogen Interactions
Plant Diseases - virology
Plant Viruses - physiology
RNA Interference
RNA, Viral - genetics
Viewpoint
Viral Proteins
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Summary:Research in virology has usually focused on one selected host-virus pathosystem to examine the mechanisms underlying a particular disease. However, as exemplified by the mechanistically versatile suppression of antiviral RNA silencing by plant viruses, there may be functionally convergent evolution. Assuming this is a widespread feature, we propose that effector proteins from diverse plant viruses can be a powerful resource for discovering new regulatory mechanisms of distinct cellular pathways. The efficiency of this approach will depend on how deeply and widely the studied pathway is integrated into viral infections. Beyond this, comparative studies using broad virus diversity should increase our global understanding of plant-virus interactions.
ISSN:0022-0957
1460-2431
1460-2431
DOI:10.1093/jxb/erz122