Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

[Display omitted] Pharmaceutical formulation of oral dosage forms is continuously challenged by the low solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid particles, are a promising alternative to surfactants for developing long-term stable emulsions that can be...

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Bibliographic Details
Published in:Journal of colloid and interface science 2023-11, Vol.650 (Pt B), p.1253-1264
Main Authors: Johannesson, Jenny, Pathare, Malhar Manik, Johansson, Mathias, Bergström, Christel A.S., Teleki, Alexandra
Format: Article
Language:English
Subjects:
3D printing
Emulsion gel
Farmaceutisk vetenskap
Fysikalisk kemi
Lipid digestion
Lipid-based formulation
Oil-in-water emulsion
Pharmaceutical Sciences
Physical Chemistry
Poorly water-soluble drug
Semi-solid extrusion
Silica nanoparticle
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Summary:[Display omitted] Pharmaceutical formulation of oral dosage forms is continuously challenged by the low solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid particles, are a promising alternative to surfactants for developing long-term stable emulsions that can be tailored for controlled release of lipophilic drugs. In this work, a non-emulsifying lipid-based formulation (LBF) loaded with fenofibrate was formulated into an oil-in-water (O/W) emulsion synergistically stabilized by stearic acid and silica (SiO2) nanoparticles. The emulsion had a droplet size of 341 nm with SiO2 particles partially covering the oil–water interface. In vitro lipid digestion was faster for the emulsion compared to the corresponding LBF due to the larger total surface area available for digestion. Cellulose biopolymers were added to the emulsion to produce a gel for semi-solid extrusion (SSE) 3D printing into tablets. The emulsion gel showed suitable rheological attributes for SSE, with a trend of higher viscosity, yield stress, and storage modulus (G′), compared to a conventional self-emulsifying lipid-based emulsion gel. The developed emulsion gel allows for a non-emulsifying LBF to be transformed into solid dosage forms for rapid lipid digestion and drug release of a poorly water-soluble drug in the small intestine.
ISSN:0021-9797
1095-7103
1095-7103
DOI:10.1016/j.jcis.2023.07.055