Cardiac Troponin-I Concentration, Myocardial Arteriosclerosis, and Fibrosis in Dogs with Congestive Heart Failure because of Myxomatous Mitral Valve Disease

• Published in: Journal of veterinary internal medicine 2013-05, Vol.27 (3), p.500-506
• Main Authors: Falk, T., Ljungvall, I., Zois, N.E., Höglund, K., Olsen, L.H., Pedersen, H. D, Häggström, J.
• Format: Article
• Language: English
• Subjects: Aldosterone - blood; Animals; Asymptomatic; Biomarkers; Cardiac and Cardiovascular Systems; Cardiac disease; Cardiovascular disease; Coronary Artery Disease - veterinary; Dog Diseases - blood; Dog Diseases - etiology; Dog Diseases - metabolism; Dog Diseases - pathology; Dogs; Endocrine system; Female; Heart failure; Heart Failure - complications; Heart Failure - veterinary; Kardiologi; Kinases; Laboratory animals; Longitudinal Studies; Male; Mitral Valve Prolapse - complications; Mitral Valve Prolapse - veterinary; Naturally occurring heart disease; Pathology; Primary Myelofibrosis - veterinary; Renin - metabolism; Troponin I - genetics; Troponin I - metabolism
• ISSN: 0891-6640; 1939-1676; 1939-1676
• DOI: 10.1111/jvim.12075

Background Few previous studies have investigated the association between biomarkers and cardiac disease findings in dogs with naturally occurring myxomatous mitral valve disease (MMVD). Aim To investigate if histopathological changes at necropsy could be reflected by in vivo circulating concentrations of cTnI and aldosterone, and renin activity, in dogs with naturally occurring congestive heart failure because of MMVD. Animals Fifty privately owned dogs with MMVD and heart failure. Methods Longitudinal Study. Dogs were prospectively recruited and examined by clinical and echocardiographical examination twice yearly until time of death. Blood was stored for batched analysis of concentrations of cTnI and aldosterone, and renin activity. All dogs underwent a standardized necropsy protocol. Results cTnI were associated with echocardiographic left ventricular end‐diastolic dimension (P