Breed Differences in Natriuretic Peptides in Healthy Dogs

BACKGROUND: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. OBJECTIVE: To investigate breed va...

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Published in:Journal of veterinary internal medicine 2014-03, Vol.28 (2), p.451-457
Main Authors: Sjöstrand, K, Wess, G, Ljungvall, I, Häggström, J, Merveille, A‐C, Wiberg, M, Gouni, V, Lundgren Willesen, J, Hanås, S, Lequarré, A‐S, Mejer Sørensen, L, Wolf, J, Tiret, L, Kierczak, M, Forsberg, S, McEntee, K, Battaille, G, Seppälä, E, Lindblad‐Toh, K, Georges, M, Lohi, Hannes, Chetboul, V, Fredholm, M, Höglund, K
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - blood
Blood & organ donations
Blood pressure
breed differences
Canine
Cardiomyopathy
cardiovascular diseases
Cavalier King Charles Spaniel
Clinical medicine
Dachshund
Doberman Pinscher
Dogs
Dogs - blood
Dogs - physiology
Dyspnea
enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
European Union
Female
Genetics
Genetik
German Shepherd
Heart failure
Interbreed variation
Intrabreed variation
Labrador Retriever
Life Sciences
Male
medicine
Médecine vétérinaire & santé animale
Natriuretic Peptide, Brain - blood
natriuretic peptides
Natriuretic Peptides - blood
NT-proBNP
Original
Peptide Fragments - blood
Peptides
Plasma
proANP 31-67
Sciences du vivant
Species Specificity
Veterinary medicine & animal health
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Summary:BACKGROUND: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. OBJECTIVE: To investigate breed variation in plasma concentrations of pro‐atrial natriuretic peptide 31‐67 (proANP 31‐67) and N‐terminal B‐type natriuretic peptide (NT‐proBNP) in healthy dogs. ANIMALS: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. METHODS: Absence of cardiovascular disease or other clinically relevant organ‐related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31‐67 and NT‐proBNP were measured by commercially available ELISA assays. RESULTS: Overall significant breed differences were found in proANP 31‐67 (P 
ISSN:0891-6640
1939-1676
1939-1676
DOI:10.1111/jvim.12310