Association analysis of KIT, MITF, and PAX3 variants with white markings in Spanish horses

Summary Several variants in the KIT, PAX3 and MITF genes have previously been associated with white markings in horses. In this study, we examined eight variants of these genes in 70 Menorca Purebred horses (PRMe, only black solid‐coloured horses) and 70 Spanish Purebred horses (PRE, different coat...

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Bibliographic Details
Published in:Animal genetics 2017-06, Vol.48 (3), p.349-352
Main Authors: Negro, S., Imsland, F., Valera, M., Molina, A., Solé, M., Andersson, L.
Format: Article
Language:English
Subjects:
Animals
Breeding
Genetic Association Studies
Genetics and Breeding
Genetik och förädling
Hair Color - genetics
Horses - genetics
Menorca Purebred
Microphthalmia-Associated Transcription Factor - genetics
Models, Genetic
PAX3 Transcription Factor - genetics
phenotypic variance
Proto-Oncogene Proteins c-kit - genetics
Purebred
SNP
Spain
white spotting
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Summary:Summary Several variants in the KIT, PAX3 and MITF genes have previously been associated with white markings in horses. In this study, we examined eight variants of these genes in 70 Menorca Purebred horses (PRMe, only black solid‐coloured horses) and 70 Spanish Purebred horses (PRE, different coat colour patterns) that were scored for the extent of white markings. A maximum‐likelihood chi‐square test, logistic regression model and ridge regression analyses showed that a missense mutation (p.Arg682His) in KIT was associated with white facial markings (P 
ISSN:0268-9146
1365-2052
1365-2052
DOI:10.1111/age.12528