Cardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease

• Published in: Journal of veterinary internal medicine 2017-05, Vol.31 (3), p.805-813
• Main Authors: Pelander, L., Häggström, J., Ley, C.J., Ljungvall, I.
• Format: Article
• Language: English
• Subjects: Animals; Azotemia; Azotemia - blood; Azotemia - veterinary; Biomarker; Blood Pressure; Cardiac and Cardiovascular Systems; Cardiovascular; Case-Control Studies; Cross-Sectional Studies; Dog Diseases - blood; Dogs; Female; Glomerular Filtration Rate - veterinary; Kardiologi; Male; Natriuretic Peptide, Brain - blood; Peptide Fragments - blood; Plasma Volume - veterinary; Renal; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - veterinary; SMALL ANIMAL; Troponin I - blood
• ISSN: 0891-6640; 1939-1676; 1939-1676
• DOI: 10.1111/jvim.14703

Background Increased concentrations of N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) and cardiac troponin I (cTnI) in dogs with azotemia have been documented. Knowledge of mechanisms behind increased concentrations of cardiac biomarkers in dogs with azotemia is warranted for correct interpretation of test results. Objectives The aim of the article was to investigate possible associations between plasma concentrations of cTnI and NT‐proBNP, respectively, and patient characteristics, glomerular filtration rate (GFR), a plasma volume factor (PVF) derived from scintigraphic examination (PVf), systolic blood pressure (SBP), selected hematologic and biochemical variables, and echocardiographic measurements in dogs with stable chronic kidney disease (CKD) and in healthy dogs. Animals Fifty student‐, staff‐, and client‐owned dogs were included. Twenty‐three of the dogs were healthy and 27 were diagnosed with CKD. Methods In this cross‐sectional observational study, dogs with a previous diagnosis of CKD and healthy control dogs were included. At inclusion, all dogs were characterized by physical examination, repeated blood pressure measurements, complete urinalysis, hematology and biochemistry panel, echocardiography, abdominal ultrasound examination of the entire urinary tract, and scintigraphic examination for measurement of GFR. Results Plasma volume factor and PCV were independently associated with NT‐proBNP (Radj2 = 0.42; P