Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension

Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The r...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-01, Vol.33 (1), p.53-59
Main Authors: Wu, Ruihua, de Faire, Ulf, Lemne, Carola, Witztum, Joseph L, Frostegard, Johan
Format: Article
Language:English
Subjects:
Antigen-Antibody Complex - analysis
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - immunology
Atherosclerosis (general aspects, experimental research)
Autoantibodies - analysis
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiolipins - immunology
Cardiology. Vascular system
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - immunology
Data Interpretation, Statistical
Enzyme-Linked Immunosorbent Assay
Epitopes - immunology
Humans
Hypertension - immunology
Immunoassay
Immunoglobulin G - analysis
Lipoproteins, LDL - immunology
Luminescent Measurements
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Oxidation-Reduction
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The role of antibodies to OxLDL during different stages of disease development is thus not clear. The objective of this study was to determine the level of aOxLDL in early cardiovascular disease, such as borderline hypertension (BHT). Seventy-three men with BHT were matched with 75 age-matched normotensive (NT) men (diastolic blood pressures, 85 to 94 and
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.33.1.53