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Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension
Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The r...
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| Published in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-01, Vol.33 (1), p.53-59 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Wu, Ruihua de Faire, Ulf Lemne, Carola Witztum, Joseph L Frostegard, Johan |
| description | Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The role of antibodies to OxLDL during different stages of disease development is thus not clear. The objective of this study was to determine the level of aOxLDL in early cardiovascular disease, such as borderline hypertension (BHT). Seventy-three men with BHT were matched with 75 age-matched normotensive (NT) men (diastolic blood pressures, 85 to 94 and |
| doi_str_mv | 10.1161/01.HYP.33.1.53 |
| format | article |
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On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The role of antibodies to OxLDL during different stages of disease development is thus not clear. The objective of this study was to determine the level of aOxLDL in early cardiovascular disease, such as borderline hypertension (BHT). Seventy-three men with BHT were matched with 75 age-matched normotensive (NT) men (diastolic blood pressures, 85 to 94 and <80 mm Hg, respectively). Antibody levels to epitopes of OxLDL were determined by use of conventional and chemiluminescence ELISA techniques. Presence of carotid atherosclerosis was determined by B-mode ultrasonography; atherosclerotic plaques were detected in 29 individuals. BHT men had significantly lower aOxLDL levels of IgG class (P=0.001) and IgM class (P=0.001) than NT controls, as determined using chemiluminescence ELISA. Similar results were obtained using conventional ELISA, with which aOxLDL of IgG (P=0.0002) and IgM (P=0.026) classes and antibody levels to malondialdehyde-LDL were significantly lower in BHT individuals. There was no difference in antibody levels between individuals with or without carotid atherosclerosis. It is not clear whether the decreased aOxLDL levels in BHT are due to a decreased immune reaction to OxLDL or to an increased consumption of aOxLDL due to binding to early atherosclerotic lesions. The possible implications of these findings are discussed. (Hypertension. 1999;33:53-59.)</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.33.1.53</identifier><identifier>PMID: 9931081</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Antigen-Antibody Complex - analysis ; Arteriosclerosis - diagnostic imaging ; Arteriosclerosis - immunology ; Atherosclerosis (general aspects, experimental research) ; Autoantibodies - analysis ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiolipins - immunology ; Cardiology. Vascular system ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - immunology ; Data Interpretation, Statistical ; Enzyme-Linked Immunosorbent Assay ; Epitopes - immunology ; Humans ; Hypertension - immunology ; Immunoassay ; Immunoglobulin G - analysis ; Lipoproteins, LDL - immunology ; Luminescent Measurements ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Oxidation-Reduction ; Ultrasonography</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1999-01, Vol.33 (1), p.53-59</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5570-574c41c910f2b4a03652c43613fa83a9f9bf270aaf4293aba6e4b3070681cd7d3</citedby><cites>FETCH-LOGICAL-c5570-574c41c910f2b4a03652c43613fa83a9f9bf270aaf4293aba6e4b3070681cd7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1688742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9931081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1937870$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Ruihua</creatorcontrib><creatorcontrib>de Faire, Ulf</creatorcontrib><creatorcontrib>Lemne, Carola</creatorcontrib><creatorcontrib>Witztum, Joseph L</creatorcontrib><creatorcontrib>Frostegard, Johan</creatorcontrib><title>Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The role of antibodies to OxLDL during different stages of disease development is thus not clear. The objective of this study was to determine the level of aOxLDL in early cardiovascular disease, such as borderline hypertension (BHT). Seventy-three men with BHT were matched with 75 age-matched normotensive (NT) men (diastolic blood pressures, 85 to 94 and <80 mm Hg, respectively). Antibody levels to epitopes of OxLDL were determined by use of conventional and chemiluminescence ELISA techniques. Presence of carotid atherosclerosis was determined by B-mode ultrasonography; atherosclerotic plaques were detected in 29 individuals. BHT men had significantly lower aOxLDL levels of IgG class (P=0.001) and IgM class (P=0.001) than NT controls, as determined using chemiluminescence ELISA. Similar results were obtained using conventional ELISA, with which aOxLDL of IgG (P=0.0002) and IgM (P=0.026) classes and antibody levels to malondialdehyde-LDL were significantly lower in BHT individuals. There was no difference in antibody levels between individuals with or without carotid atherosclerosis. It is not clear whether the decreased aOxLDL levels in BHT are due to a decreased immune reaction to OxLDL or to an increased consumption of aOxLDL due to binding to early atherosclerotic lesions. The possible implications of these findings are discussed. (Hypertension. 1999;33:53-59.)</description><subject>Antigen-Antibody Complex - analysis</subject><subject>Arteriosclerosis - diagnostic imaging</subject><subject>Arteriosclerosis - immunology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Autoantibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Cardiolipins - immunology</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - immunology</subject><subject>Data Interpretation, Statistical</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epitopes - immunology</subject><subject>Humans</subject><subject>Hypertension - immunology</subject><subject>Immunoassay</subject><subject>Immunoglobulin G - analysis</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>Ultrasonography</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kVFrFDEUhYModa2--iYMIr7NmDtJJsnj2qpbWKiCoj6FTOYOm3Z2sk1mXPvvTdm1BcFAyE3udw5JDiEvgVYADbyjUK1-fq4Yq6AS7BFZgKh5yUXDHpMFBc1LDfDjKXmW0hWlwDmXJ-REawZUwYJ8Wc5TsOPk29B5TMUUisvf6_N1sYxYnKOLaBN2hR-Li7Hzv3w32yEV3_20Kd6H2GEc_IjF6naHccIx-TA-J0_6zOCL43pKvn388PVsVa4vP12cLdelE0LSUkjuODgNtK9bbilrRO04a4D1VjGre932taTW9rzWzLa2Qd4yKmmjwHWyY6ekPPimPe7m1uyi39p4a4L15nh0nSs0nNUc6szL__K7GLoH0V8haCaVpFn59qDM2M2MaTJbnxwOgx0xzMk0WkgFSmTw9T_gVZjjmH_B1FQwCkqqDFUHyMWQUsT-_iZAzV2khoLJkRrGDBjBsuDV0XVut9jd48cMc__NsW-Ts0Mf7eh8enBtlJL87v38gO3DMGFM18O8x2g2aIdpY2gevG5UCVprCnlX5gmU_QGvLbij</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Wu, Ruihua</creator><creator>de Faire, Ulf</creator><creator>Lemne, Carola</creator><creator>Witztum, Joseph L</creator><creator>Frostegard, Johan</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>199901</creationdate><title>Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension</title><author>Wu, Ruihua ; de Faire, Ulf ; Lemne, Carola ; Witztum, Joseph L ; Frostegard, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5570-574c41c910f2b4a03652c43613fa83a9f9bf270aaf4293aba6e4b3070681cd7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antigen-Antibody Complex - analysis</topic><topic>Arteriosclerosis - diagnostic imaging</topic><topic>Arteriosclerosis - immunology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Autoantibodies - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Cardiolipins - immunology</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - immunology</topic><topic>Data Interpretation, Statistical</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epitopes - immunology</topic><topic>Humans</topic><topic>Hypertension - immunology</topic><topic>Immunoassay</topic><topic>Immunoglobulin G - analysis</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Ruihua</creatorcontrib><creatorcontrib>de Faire, Ulf</creatorcontrib><creatorcontrib>Lemne, Carola</creatorcontrib><creatorcontrib>Witztum, Joseph L</creatorcontrib><creatorcontrib>Frostegard, Johan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Ruihua</au><au>de Faire, Ulf</au><au>Lemne, Carola</au><au>Witztum, Joseph L</au><au>Frostegard, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1999-01</date><risdate>1999</risdate><volume>33</volume><issue>1</issue><spage>53</spage><epage>59</epage><pages>53-59</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Elevated antibody levels to oxidized low-density lipoprotein (aOxLDL) have been shown to correlate with the degree of atherosclerosis in some studies. On the other hand, immunization of experimental animals with OxLDL, leading to enhanced aOxLDL levels, inhibits the development of the disease. The role of antibodies to OxLDL during different stages of disease development is thus not clear. The objective of this study was to determine the level of aOxLDL in early cardiovascular disease, such as borderline hypertension (BHT). Seventy-three men with BHT were matched with 75 age-matched normotensive (NT) men (diastolic blood pressures, 85 to 94 and <80 mm Hg, respectively). Antibody levels to epitopes of OxLDL were determined by use of conventional and chemiluminescence ELISA techniques. Presence of carotid atherosclerosis was determined by B-mode ultrasonography; atherosclerotic plaques were detected in 29 individuals. BHT men had significantly lower aOxLDL levels of IgG class (P=0.001) and IgM class (P=0.001) than NT controls, as determined using chemiluminescence ELISA. Similar results were obtained using conventional ELISA, with which aOxLDL of IgG (P=0.0002) and IgM (P=0.026) classes and antibody levels to malondialdehyde-LDL were significantly lower in BHT individuals. There was no difference in antibody levels between individuals with or without carotid atherosclerosis. It is not clear whether the decreased aOxLDL levels in BHT are due to a decreased immune reaction to OxLDL or to an increased consumption of aOxLDL due to binding to early atherosclerotic lesions. The possible implications of these findings are discussed. (Hypertension. 1999;33:53-59.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>9931081</pmid><doi>10.1161/01.HYP.33.1.53</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 1999-01, Vol.33 (1), p.53-59 |
| issn | 0194-911X 1524-4563 |
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| source | EZB Electronic Journals Library |
| subjects | Antigen-Antibody Complex - analysis Arteriosclerosis - diagnostic imaging Arteriosclerosis - immunology Atherosclerosis (general aspects, experimental research) Autoantibodies - analysis Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiolipins - immunology Cardiology. Vascular system Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - immunology Data Interpretation, Statistical Enzyme-Linked Immunosorbent Assay Epitopes - immunology Humans Hypertension - immunology Immunoassay Immunoglobulin G - analysis Lipoproteins, LDL - immunology Luminescent Measurements Male Medical sciences Medicin och hälsovetenskap Middle Aged Oxidation-Reduction Ultrasonography |
| title | Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension |
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