The effect of unloading on protein synthesis in human skeletal muscle

Atrophy of skeletal muscle is observed in response to immobilization and lack of weight‐bearing. The aim of this study was to investigate the effect of immobilization on muscle protein synthesis and associated biochemical parameters in skeletal muscle of healthy volunteers employing a standardized m...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1998-07, Vol.163 (4), p.369-377
Main Authors: Gamrin, L., Berg, H.E., Essén, P., Tesch, P.A., Hultman, E., Garlick, P.J., McNurlan, M.A., Wernerman, And J.
Format: Article
Language:English
Subjects:
Adult
Amino Acids - metabolism
biochemical markers
Biological and medical sciences
Energy Metabolism - physiology
Fundamental and applied biological sciences. Psychology
Humans
Leg
Male
Medicin och hälsovetenskap
muscle protein synthesis
Muscle Proteins - biosynthesis
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Nucleic Acids - metabolism
Phosphates - metabolism
Reference Values
Ribosomes - metabolism
Space life sciences
Striated muscle. Tendons
unloading
Vertebrates: osteoarticular system, musculoskeletal system
Weight-Bearing - physiology
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Summary:Atrophy of skeletal muscle is observed in response to immobilization and lack of weight‐bearing. The aim of this study was to investigate the effect of immobilization on muscle protein synthesis and associated biochemical parameters in skeletal muscle of healthy volunteers employing a standardized model of lower limb unloading. One leg was unloaded for 10 days, and percutaneous muscle biopsies were taken before and at the end of the unloading period. The capacity for protein synthesis, as reflected by the concentration of RNA, decreased by 16% (P 
ISSN:0001-6772
1365-201X
1365-201X
DOI:10.1046/j.1365-201X.1998.t01-1-00391.x