Human Histone Deacetylase 2,HDAC2(HumanRPD3), Is Localized to 6q21 by Radiation Hybrid Mapping

• Published in: Genomics (San Diego, Calif.) Calif.), 1998-09, Vol.52 (2), p.245-246
• Main Authors: Betz, Regina, Gray, Steven G., Ekström, Christina, Larsson, Catharina, Ekström, Tomas J.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; chromosome 1; chromosome 6; Chromosome Mapping; Chromosomes, Human, Pair 6 - genetics; Classical genetics, quantitative genetics, hybrids; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; HDAC1 gene; HDAC2 gene; histone deacetylase; Histone Deacetylases - genetics; Human; Humans; Hybrid Cells; Medicin och hälsovetenskap; RPD3 gene
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1998.5435

Histone acetyltransferase genes (HATs) and histone deacetylase genes (HDACs) act to modulate chromatin structure (5). The current notion is that histone acetyltransferase activity is associated with transcriptional activation and histone deacetylation with re-pression. The model relies on various observations showing that a more open chromatin structure occurs when histones are acetylated. Recent reports have demonstrated the involvement of these genes in human neoplasia, particularly leukemia (2, 3). So far, three major histone deacetylases have been cloned in human, HDAC1, HDAC2 (also called human RPD3), and HDAC3. The documented importance of histone deacetylase activity prompted us to locate this gene in the human genome as a first step to evaluate its relevance in human disease. By using a radiation hybrid panel, we have mapped HDAC2 to human chromosome 6q21. The human 6q21 region is syntenic with the region on mouse chromosome 10 to which the murine homologue has been mapped. HDAC1 has been mapped to 1p34.1 and HDAC3 to 5q32 but the locations of the corresponding murine loci have not been published.