β-Thromboglobulin in Urine and Plasma: Influence of Coronary Risk Factors

• Published in: Thrombosis research 1998-06, Vol.90 (5), p.229-237
• Main Authors: Mundal, Håvard Holth, Hjemdahl, Paul, Urdal, Petter, Kierulf, Peter, Perneby, Christina, Berg, Kåre, Gjesdal, Knut
• Format: Article
• Language: English
• Subjects: Adult; beta-Thromboglobulin - metabolism; Biological and medical sciences; Blood coagulation. Blood cells; Blood Pressure; Cigarette smoking; Coronary Disease - blood; Coronary Disease - etiology; Coronary Disease - urine; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods, hemostasis, fibrinolysis; Humans; Lipoproteins; Male; Medicin och hälsovetenskap; Molecular and cellular biology; Multivariate Analysis; Platelet Activation; Platelet volume; Risk Factors; Smoking; β-thromboglobulin
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(98)00062-0

Blood platelet activation in vivo was evaluated by measuring β-thromboglobulin in plasma and high molecular weight β-thromboglobulin in urine in hypertensive smoking and nonsmoking middle-aged men n=36 and in normotensive age-matched controls n=40 . We found no significant linear relationships between nocturnal or resting urinary high molecular weight β-thromboglobulin and plasma β-thromboglobulin in the combined hypertensive and normotensive groups. The excretion of high molecular weight β-thromboglobulin correlated significantly with diastolic blood pressure when all subjects were pooled. After 60 minutes supine rest, nonsmokers had higher excretion of high molecular weight β-thromboglobulin than smokers. Plasma β-thromboglobulin levels tended to be higher in hypertensives. In multivariate analyses, resting high molecular weight β-thromboglobulin excretion was positively related to diastolic blood pressure and negatively related to smoking, whereas plasma β-thromboglobulin was positively related to diastolic blood pressure and inversely related to apolipoprotein A1 and B. We conclude that urinary high molecular weight β-thromboglobulin and plasma β-thromboglobulin are not closely related, but are complementary analyses, as there are methodological confounders for both variables.