Chimaeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model

Hantaviruses are rodent-born agents which are pathogenic in humans causing haemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome. To induce a protective immunity against a European hantavirus (Puumala) we constructed chimaeric hepatitis B virus (HBV) core particles carrying defined...

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Bibliographic Details
Published in:Vaccine 1998-01, Vol.16 (2), p.272-280
Main Authors: Ulrich, Rainer, Lundkvist, Åke, Meisel, Helga, Koletzki, Diana, Brus Sjölander, Katarina, Gelderblom, Hans R., Borisova, Galina, Schnitzler, Paul, Darai, Gholamreza, Krüger, Detlev H.
Format: Article
Language:English
Subjects:
Animals
Arvicolinae
Biological and medical sciences
chimaeric virus-like particles
Fundamental and applied biological sciences. Psychology
hantavirus
Hantavirus - immunology
Hantavirus Infections - immunology
Hantavirus Infections - prevention & control
Hepatitis B Core Antigens - immunology
Medicin och hälsovetenskap
Microbiology
Nucleocapsid - immunology
protective immunity
Recombinant Fusion Proteins - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
Virology
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Summary:Hantaviruses are rodent-born agents which are pathogenic in humans causing haemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome. To induce a protective immunity against a European hantavirus (Puumala) we constructed chimaeric hepatitis B virus (HBV) core particles carrying defined fragments of the Puumala virus nucleocapsid protein. After immunisation of bank voles, the natural host of Puumala virus, with core particles possessing an insertion of the N-terminal part of Puumala virus nucleocapsid protein, four of five animals were protected against subsequent virus challenge. The results show that the major protective region of the nucleocapsid protein is located between amino acids 1 and 45 and that chimaeric HBV core-like particles are useful carries of foreign protective epitopes.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(97)00172-2