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Prenatal corticosterone treatment induces long-term changes in spontaneous and apomorphine-mediated motor activity in male and female rats

The potential influence of glucocorticoids on fetal brain development was investigated after corticosterone administration via pellets to pregnant rats during the last trimester of gestation. We examined both spontaneous motor activity and dopamine-mediated motor responses to apomorphine, a predomin...

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Bibliographic Details
Published in:Neuroscience 1997-11, Vol.81 (1), p.129-140
Main Authors: Diaz, R, Fuxe, K, Ă–gren, S.O
Format: Article
Language:English
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Summary:The potential influence of glucocorticoids on fetal brain development was investigated after corticosterone administration via pellets to pregnant rats during the last trimester of gestation. We examined both spontaneous motor activity and dopamine-mediated motor responses to apomorphine, a predominantly D 1 and D 2 receptor agonist, given at a postsynaptic dose (1 mg/kg, s.c.) to both prepubertal and adult male and female offspring. Prenatal corticosterone was found to produce the following alterations in the offspring: (1) Prepubertal stage: Male offspring: A statistically significant ( P
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(97)00141-3