Oral administration of antibodies as prophylaxis and therapy in Campylobacter jejuni‐infected chickens

Passive immunity against gastrointestinal infections has recently been successfully applied as prophylaxis and therapy in patients in a variety of virally and bacterially induced infections. Campylobacter jejuni is frequently associated with acute diarrhoea in humans, and several species of animals...

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Bibliographic Details
Published in:Clinical and experimental immunology 1997-06, Vol.108 (3), p.451-455
Main Authors: TSUBOKURA, K., BERNDTSON, E., BOGSTEDT, A., KAIJSER, B., KIM, M., OZEKI, M., HAMMARSTRÖM, L.
Format: Article
Language:English
Subjects:
Administration, Oral
Animal bacterial diseases
Animals
Antibodies, Bacterial - therapeutic use
Bacterial diseases
Biological and medical sciences
Campylobacter
Campylobacter Infections - prevention & control
Campylobacter Infections - therapy
Campylobacter jejuni
Campylobacter jejuni - immunology
Cattle
Chickens
Female
Immunization, Passive
immunoprophylaxis
Infectious diseases
Medical sciences
Medicin och hälsovetenskap
Original
passive immunity
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Summary:Passive immunity against gastrointestinal infections has recently been successfully applied as prophylaxis and therapy in patients in a variety of virally and bacterially induced infections. Campylobacter jejuni is frequently associated with acute diarrhoea in humans, and several species of animals have been shown to transmit the disease, although birds have been implicated as the main source of infection. We used bovine and chicken immunoglobulin preparations from the milk and eggs, respectively, of immunized animals for prophylactic and therapeutic treatment of chickens infected with C. jejuni. A marked prophylactic effect (a >99% decrease in the number of bacteria) was noted using either antibody preparation, whereas the therapeutic efficacy, i.e. when antibodies were given after the infection was established, was distinctly lower (80–95%) as judged by faecal bacterial counts. These observations may serve as a starting point for experiments aimed at elimination of the infection in an industrial or farm setting. It may also encourage future attempts to treat, prophylactically or therapeutically, patients with Campylobacter‐induced diarrhoea.
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1997.3901288.x