13q deletions in lymphoid malignancies

Previous studies have indicated that a candidate tumor suppressor gene resides telomeric of the RB1 gene at 13q14, a region that is commonly deleted in B-cell chronic lymphocytic leukemia (B-CLL). In this study, we have evaluated the frequency and minimal region of overlap for 13q deletions in malig...

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Bibliographic Details
Published in:Blood 1995-09, Vol.86 (5), p.1911-1915
Main Authors: YIE LIU, HERMANSON, M, NIKIFOROVA, N, BUYS, C, SÖDERHÄLL, S, YANKOVSKY, N, ZABAROVSKY, E, EINHORN, S, GRANDER, D, MERUP, M, XIUSHAN WU, HEYMAN, M, RASOOL, O, JULIUSSON, G, GAHRTON, G, DETLOFSSON, R
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Burkitt Lymphoma - genetics
Cell Line
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 13
DNA Primers
DNA Probes
DNA, Satellite - genetics
Genetic Carrier Screening
Hematologic and hematopoietic diseases
Homozygote
Humans
Leukemia-Lymphoma, Adult T-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell - genetics
Lymphoma, T-Cell - genetics
Medical sciences
Medicin och hälsovetenskap
Molecular Sequence Data
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Tumor Cells, Cultured
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Summary:Previous studies have indicated that a candidate tumor suppressor gene resides telomeric of the RB1 gene at 13q14, a region that is commonly deleted in B-cell chronic lymphocytic leukemia (B-CLL). In this study, we have evaluated the frequency and minimal region of overlap for 13q deletions in malignant cells from various lymphoid neoplasms. We observed losses at 13q14 in 33/75 (44%) B-CLL cases, four of 16 (25%) non-Hodgkin's lymphoma (NHL) cases, eight of 29 (28%) patients with acute lymphocytic leukemia (ALL), and one of 15 T-cell lines. In some ALL cases, inactivation of the RB1 gene is suggested as the important event in the 13q deletions. The most commonly deleted marker in CLL and NHL was D13S319, between RBkpt and the D13S25 loci. Homozygous deletions of this marker were observed in 10 of 75 B-CLL cases, in six of which the homozygous deletions included only the D13S319 locus. Our data suggest that 13q deletions are common in lymphoid neoplasms, and that deletion of a candidate tumor suppressor gene(s) in the vicinity of the D13S319 marker is a tumorigenic event in these diseases.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v86.5.1911.bloodjournal8651911